Recombinant Renal Cell Carcinoma (Gp200) antibody
The Mouse Monoclonal anti-Renal Cell Carcinoma (Gp200) antibody (Clone rPN-15) (ABIN7865158) specifically detects Renal Cell Carcinoma (Gp200) in IHC.
The antibody is reactive with Human and Horse samples.
Catalog No. ABIN7865158
$640.46
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Quick Overview for Recombinant Renal Cell Carcinoma (Gp200) antibody (ABIN7865158)
Target
Renal Cell Carcinoma (Gp200)
Antibody Type
Recombinant Antibody
Reactivity
Human, Horse
Host
Mouse
Clonality
Monoclonal
Conjugate
Un-conjugated
Application
Immunohistochemistry (IHC)
Clone
RPN-15
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Purpose
- Recombinant Renal Cell Carcinoma (Carbonic Anhydrase IX) Antibody
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Specificity
- Recognizes a glycoprotein of ~200kDa, identified as carbonic anhydrase IX (CAIX/gp200). Its epitope resides in the carbohydrate domain of gp200. It shows no significant cross-reactivity with other carbohydrate determinants, such as the Lewis blood group antigens, epithelial membrane antigen, HMFG, and AB blood group antigens. In normal kidney, gp200 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowman's capsule adjoining the outgoing proximal tubule. Reportedly, gp200 is expressed by 93% of primary and 84% of metastatic renal cell carcinomas. This MAb may be useful in the investigations of carcinomas of proximal nephrogenic differentiation especially those showing tubular differentiation.
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Purification
- 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.
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Immunogen
- Recombinant full-length human CA9 protein
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Isotype
- IgG2b, kappa
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Concentration
- 200 μg/mL
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Buffer
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C
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Storage Comment
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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Expiry Date
- 24 months
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- Renal Cell Carcinoma (Gp200)
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Alternative Name
- Renal Cell Carcinoma
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Background
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CA-IX, CA9, CAIX, Carbonate dehydratase IX, Carbonic anhydrase 9, Carbonic anhydrase IX, Carbonic dehydratase, G250, Membrane antigen MN, P54/58N, pMW1, RCC-associated antigen G250, Renal cell carcinoma-associated antigen G250
Normal kidney or renal cell carcinoma (IHC).
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Molecular Weight
- 55kDa
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Gene ID
- 768, 63287
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UniProt
- Q16790
Target
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