SOD1 antibody

Catalog No. ABIN7864060

The Mouse Monoclonal anti-SOD1 antibody (Clone SOD1-4593) (ABIN7864060) specifically detects SOD1 in IHC. The antibody is reactive with Human samples.

Quick Overview for SOD1 antibody (ABIN7864060)

Target: SOD1 (Superoxide Dismutase 1, Soluble (SOD1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SOD1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: SOD1-4593

Product Details anti-SOD1 Antibody

Purpose: Superoxide Dismutase 1 (SOD1) (Antioxidant Enzyme) Antibody

Specificity: Cu-Zn superoxide dismutase-1 (SOD-1) is a well-characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Enzymatically, SOD-1 facilitates the dismutation of oxygen radicals to hydrogen peroxide and also catalyzes pro-oxidant reactions, which include the peroxidase activity and hydroxyl radical generating activity. SOD-1 is ubiquitously expressed in somatic cells and functions as a homodimer. Defects in the gene encoding SOD-1 have been implicated in the progression of neurological diseases, including amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by the loss of spinal motor neurons, Down syndrome and Alzheimer s disease. In familial ALS, several mutations in SOD-1 predominate, resulting in the loss of zinc binding, the loss of scavenging activity of SOD-1, and correlate with an increase in neurotoxicity and motor neuron death.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human SOD1 protein

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for SOD1

Target: SOD1 (Superoxide Dismutase 1, Soluble (SOD1))

Alternative Name: Superoxide Dismutase 1

Background:

Amyotrophic lateral sclerosis 1 (ALS1), Cu/Zn SOD, Cu/Zn Superoxide Dismutase, Epididymis Secretory Protein Li 44, Indophenoloxidase A (IPOA), Superoxide Dismutase [Cu-Zn], Superoxide Dismutase 1 (SOD1)

HeLa or Jurkat cells. Human breast or ovarian carcinoma

Molecular Weight: 16kDa

Gene ID: 6647, 443914

UniProt: P00441

Pathways: Sensory Perception of Sound, Transition Metal Ion Homeostasis