Recombinant TLR4 antibody

Catalog No. ABIN7863457

The Rabbit Monoclonal anti-TLR4 antibody is suitable to detect TLR4 in samples from Human, Rat, Dog, Pig, Guinea Pig and Monkey. It has been validated for ELISA.

Quick Overview for Recombinant TLR4 antibody (ABIN7863457)

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Antibody Type: Recombinant Antibody

Reactivity: Human, Rat, Dog, Pig, Guinea Pig, Monkey

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TLR4 antibody is un-conjugated

Application: ELISA

Clone: TLR4-3895R

Product Details anti-TLR4 Antibody

Purpose: Recombinant CD284 (Toll-Like Receptor 4) Antibody

Specificity: This MAb reacts with human Toll-like receptor 2 (TLR4). It is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human TLR4 protein

Isotype: IgG, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for TLR4

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Alternative Name: CD284

Background:

ARMD10, CD284, hToll, TLR4, TOLL, Toll Endotoxin Hyporesponsiveness, Toll-like receptor 4

HeLa, human peripheral blood cells. Dendritic cells, macrophage and monocytes in tonsil, placenta and adrenal., PC12

Molecular Weight: 95-120kDa

Gene ID: 7099, 174312

UniProt: O00206

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins