beta Amyloid antibody (AA 1-100)

Catalog No. ABIN7862345

This Mouse Monoclonal antibody specifically detects beta Amyloid in IHC. It exhibits reactivity toward Human.

Quick Overview for beta Amyloid antibody (AA 1-100) (ABIN7862345)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta Amyloid antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: APP-4469

Product Details anti-beta Amyloid Antibody

Binding Specificity: AA 1-100

Purpose: beta Amyloid Antibody

Specificity: Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the ≤-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the 4 kDa Amyloid ≤/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP. Human APLP2 is a membrane-bound sperm protein that contains a region highly homologous to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer s disease patients.

Purification: 200ug/ml of Ab purified from rabbit anti-serum by Protein A.

Immunogen: Recombinant fragment (around aa1-100) of human APP protein (exact sequence is proprietary). Recognizes an epitope in the region 8-16 of the amyloid precursor protein.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Preservative: Azide free

Storage: -20 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Target Details for beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Alternative Name: beta Amyloid

Background:

CVAP, AAA, AICD-50, PN2, 50, Beta-APP42, AID, S-APP-alpha, 57, AD1, PN-II, Beta-APP40, 42, 40, APPI, Alzheimer disease amyloid protein, PreA4, ABETA, Amyloid intracellular domain 50, 57, 59 AICD-59, S-APP-beta, APP, AICD-57, ABPP, Protease nexin-II, Cerebral vascular amyloid peptide

Alzheimer's diseased brain. Amyloidosis.

Molecular Weight: 4-46kDa (≤-Amyloid), 100-125kDa (Amyloid A4)

Gene ID: 351, 434980

UniProt: P05067

Pathways: Inflammasome