beta Amyloid antibody (AA 578-680)

Catalog No. ABIN7862986

This Mouse Monoclonal antibody specifically detects beta Amyloid in IHC, IF and FACS. It exhibits reactivity toward Human.

Quick Overview for beta Amyloid antibody (AA 578-680) (ABIN7862986)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta Amyloid antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: APP-3345

Product Details anti-beta Amyloid Antibody

Binding Specificity: AA 578-680

Purpose: beta Amyloid Antibody

Specificity: Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the æ-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the 4 kDa Amyloid æ/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP. Human APLP2 is a membrane-bound sperm protein that contains a region highly homologous to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer s disease patients.

Purification: 200ug/ml of Ab purified from rabbit anti-serum by Protein A.

Immunogen: Recombinant fragment (around aa578-680) of human Amyloid Beta protein (exact sequence is proprietary)

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Alternative Name: beta Amyloid

Background:

CVAP; AAA; AICD-50; PN2; 50; Beta-APP42; AID; S-APP-alpha; 57; AD1; PN-II; Beta-APP40; 42; 40; APPI; Alzheimer disease amyloid protein; PreA4; ABETA; Amyloid intracellular domain 50; 57; 59 AICD-59; S-APP-beta; APP; AICD-57; ABPP; Protease nexin-II; Cerebral vascular amyloid peptide

Alzheimer's disease brain. Amyloidosis.

Molecular Weight: 4-46kDa (•æ-Amyloid), 100-125kDa (Amyloid A4)

Gene ID: 351, 434980

UniProt: P05067

Pathways: Inflammasome