Progesterone Receptor antibody

Catalog No. ABIN7865720

This Mouse Monoclonal antibody specifically detects Progesterone Receptor in IHC. It exhibits reactivity toward Human.

Quick Overview for Progesterone Receptor antibody (ABIN7865720)

Target: Progesterone Receptor (PGR)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Progesterone Receptor antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: PR-80

Product Details anti-Progesterone Receptor Antibody

Purpose: anti-Progesterone Receptor mouse monoclonal, PR-80, purified

Purification: affinity chromatography

Immunogen: recombinant human progesterone receptor protein

Isotype: IgG1 kappa

Application Details

Application Notes:

IHC-paraffin_dilution: 1:25-1:50 (2-4 μg/mL, microwave treatment in 10 mM citrate buffer pH 6.0 recommended)

IHC-frozen_dilution: 1:25-1:50 (2-4 μg/mL)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100 μg/mL

Buffer: PBS with 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: store at 2 - 8 °C

Target Details for Progesterone Receptor

Target: Progesterone Receptor (PGR)

Alternative Name: Progesterone Receptor

Background: PR-80 is specific to progesterone receptor and shows minimal cross-reaction with other members of the family. Progesterone receptor is expressed as two major isoforms, PR-A (81 kDa) and PR-B (116 kDa). Expression of PgR has been suggested to reflect an intact estrogen regulatory machinery and therefore, predict better clinical response to endocrine therapy than ER alone. Positive control: PR positive breast cancer, T47-D cells.

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration