Recombinant Complement Factor B antibody (PE)

Catalog No. ABIN7867224

The Rabbit Chimeric anti-Complement Factor B antibody is suitable to detect Complement Factor B in samples from Human. It has been validated for FACS.

Quick Overview for Recombinant Complement Factor B antibody (PE) (ABIN7867224)

Target: Complement Factor B (CFB)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This Complement Factor B antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: DMC366

Product Details anti-Complement Factor B Antibody (PE)

Purpose: PE-conjugated Anti-CFB antibody(DMC366), IgG1 Chimeric mAb

Purification: Purified from cell culture supernatant by affinity chromatography

Isotype: IgG1

Application Details

Application Notes: Flow Cyt 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid PBS with 0.05 %  Proclin300, 1 % BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2°C-8°C for 6 months

Expiry Date: 6 months

Target Details for Complement Factor B

Target: Complement Factor B (CFB)

Alternative Name: CFB

Background:

Synonyms: AHUS4, ARMD14, BF, BFD, CFAB, CFBD, FB, FBI12, GBG, H2-Bf, PBF2

Target Background: This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

UniProt: P00751

Pathways: Complement System, Proton Transport, Ribonucleoside Biosynthetic Process