FHIT antibody (AA 1-147)

Catalog No. ABIN7868171

This Mouse Monoclonal antibody specifically detects FHIT in WB, IF and FACS. It exhibits reactivity toward Human.

Quick Overview for FHIT antibody (AA 1-147) (ABIN7868171)

Target: FHIT (Fragile Histidine Triad (FHIT))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FHIT antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: 26H7

Product Details anti-FHIT Antibody

Binding Specificity: AA 1-147

Purpose: FHIT Antibody

Purification: Protein G affinity

Immunogen: Human FHIT recombinant protein (amino acids M1-Q147) was used as the immunogen for the FHIT antibody antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the FHIT antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the FHIT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for FHIT

Target: FHIT (Fragile Histidine Triad (FHIT))

Alternative Name: FHIT

Background: Bis(5'-adenosyl)-triphosphatase, also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by the FHIT gene. This gene, a member of the histidine triad gene family, encodes a diadenosine P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3p14.2, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Furthermore, FHIT has been shown to synergize with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. It also acts as a tumor suppressor of HER2/neu driven breast cancer.

UniProt: P49789