PON1 antibody (AA 1-200)

Catalog No. ABIN7868701

The Mouse Monoclonal anti-PON1 antibody (Clone PON1-1351) (ABIN7868701) specifically detects PON1 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for PON1 antibody (AA 1-200) (ABIN7868701)

Target: PON1 (Paraoxonase 1 (PON1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PON1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PON1-1351

Product Details anti-PON1 Antibody

Binding Specificity: AA 1-200

Purpose: Paraoxonase 1 Antibody / PON1

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the Paraoxonase 1 antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the Paraoxonase 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Paraoxonase 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PON1

Target: PON1 (Paraoxonase 1 (PON1))

Alternative Name: Paraoxonase 1

Background: Paroxon is an organophosphorus anticholinesterase compound, used topically in the treatment of glaucoma. It is produced in vivo in mammals by microsomal oxidation of the insecticide parathion. Parathion is inert until transformed to paroxon. Paroxonase or PON is an arylesterase that is capable of hydrolyzing paroxon to produce p-nitrophenol. PONs are nonspecific and their classification is based not only on substrate specificity but also on tissue distribution, inhibition properties and physicochemical characteristics such as electrophoretic mobility and molecular weight. In contrast to PON1, which is expressed mainly in the liver, PON2 is expressed in a variety of mouse tissues, including the pancreas. PON3 is a associated with the high density lipoprotein fraction of serum. The genes which encode PON1-3 are physically linked and map to human chromosome 7q21.3.

UniProt: P27169