Recombinant TYMS antibody (AA 1-200)

Catalog No. ABIN7868769

The Rabbit Monoclonal anti-TYMS antibody is suitable to detect TYMS in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant TYMS antibody (AA 1-200) (ABIN7868769)

Target: TYMS (Thymidylate Synthetase (TYMS))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TYMS antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TYMS-9091R

Product Details anti-TYMS Antibody

Binding Specificity: AA 1-200

Purpose: Recombinant Thymidylate Synthase Antibody / TYMS

Purification: Protein A/G affinity

Immunogen: A recombinant human thymidylate synthase protein fragment (within amino acids 1-200) was used as the immunogen for the recombinant Thymidylate Synthase antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant Thymidylate Synthase antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant Thymidylate Synthase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TYMS

Target: TYMS (Thymidylate Synthetase (TYMS))

Alternative Name: Thymidylate Synthase

Background: It recognizes a protein of 36 kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

UniProt: P04818

Pathways: Mitotic G1-G1/S Phases