Recombinant TRIM29 antibody (AA 1-200)

Catalog No. ABIN7868783

This Rabbit Monoclonal antibody specifically detects TRIM29 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant TRIM29 antibody (AA 1-200) (ABIN7868783)

Target: TRIM29 (Tripartite Motif Containing 29 (TRIM29))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TRIM29 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TRIM29-9256R

Product Details anti-TRIM29 Antibody

Binding Specificity: AA 1-200

Purpose: Recombinant TRIM29 Antibody / Tripartite motif-containing protein 29

Purification: Protein A/G affinity

Immunogen: A recombinant fragment (within amino acids 1-200) of human TRIM29 protein was used as the immunogen for the recombinant TRIM29 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant TRIM29 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant TRIM29 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TRIM29

Target: TRIM29 (Tripartite Motif Containing 29 (TRIM29))

Alternative Name: TRIM29

Background: Tripartite motif-containing protein 29 (TRIM29) interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90 % positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies.

UniProt: Q14134

Pathways: p53 Signaling, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus