BAG2 antibody (AA 1-211)

Catalog No. ABIN7868825

This Mouse Monoclonal antibody specifically detects BAG2 in WB and FACS. It exhibits reactivity toward Human and Mouse.

Quick Overview for BAG2 antibody (AA 1-211) (ABIN7868825)

Target: BAG2 (BCL2-Associated Athanogene 2 (BAG2))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This BAG2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: 8F11G2

Product Details anti-BAG2 Antibody

Binding Specificity: AA 1-211

Purpose: BAG2 Antibody

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids M1-N211) was used as the immunogen for the BAG2 antibody.

Isotype: IgG1

Application Details

Application Notes: Optimal dilution of the BAG2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the BAG2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for BAG2

Target: BAG2 (BCL2-Associated Athanogene 2 (BAG2))

Alternative Name: BAG2

Background: BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The functional antagonisms displayed between BAG family proteins and Hip suggest that a proper balance of these 2 types of protein is required for achieving optimal cycles of substrate binding and release required for inducting conformational changes in proteins, with Hip promoting peptide substrate binding by Hsc70/Hsp70 and BAG family proteins promoting dissociation.

UniProt: O95816