PARVG antibody (AA 1-280)

Catalog No. ABIN7869042

The Rabbit Polyclonal anti-PARVG antibody is suitable to detect PARVG in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and FACS.

Quick Overview for PARVG antibody (AA 1-280) (ABIN7869042)

Target: PARVG (Parvin, gamma (PARVG))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARVG antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-PARVG Antibody

Binding Specificity: AA 1-280

Purpose: PARVG Antibody / Gamma Parvin

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human PARVG recombinant protein (Position: M1-E280) was used as the immunogen for the PARVG antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PARVG antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PARVG antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PARVG

Target: PARVG (Parvin, gamma (PARVG))

Alternative Name: PARVG

Background: PARVG antibody detects Gamma-parvin, a cytoskeletal adaptor protein that links integrins to actin filaments and regulates cell adhesion, motility, and signaling. The UniProt recommended name is Gamma-parvin (PARVG). This protein is a member of the parvin family of actin-binding proteins associated with focal adhesions and integrin-linked kinase (ILK) complexes.

Functionally, PARVG antibody identifies a 372-amino-acid cytoplasmic protein containing two calponin-homology (CH) domains that mediate actin binding and integrin interaction. PARVG participates in integrin-mediated adhesion signaling, influencing cell spreading, migration, and cytoskeletal dynamics. It contributes to mechanotransduction pathways in endothelial and immune cells.

The PARVG gene is located on chromosome 22q13.31 and is expressed in leukocytes, vascular smooth muscle cells, and skeletal muscle. PARVG regulates integrin activation and focal adhesion turnover, playing a key role in immune cell motility and vascular integrity.

Pathologically, altered PARVG expression has been linked to cancer cell migration, vascular remodeling, and inflammatory responses. Dysregulation of PARVG contributes to defective adhesion signaling and cytoskeletal organization. Research using PARVG antibody supports studies in integrin signaling, cytoskeletal remodeling, and vascular biology.

PARVG antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect cytoskeletal and adhesion-associated proteins. NSJ Bioreagents provides PARVG antibody reagents optimized for research in adhesion signaling, actin dynamics, and immune cell motility.

Structurally, Gamma-parvin contains CH1 and CH2 domains that facilitate actin binding and ILK-PINCH complex formation. This antibody aids in analyzing PARVG's function in integrin-linked cytoskeletal networks and adhesion regulation.

UniProt: Q9HBI0