CDK12 antibody (AA 1-30)

Catalog No. ABIN7869083

This Rabbit Polyclonal antibody specifically detects CDK12 in WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for CDK12 antibody (AA 1-30) (ABIN7869083)

Target: CDK12 (CRKRS) (Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK12 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CDK12 Antibody

Binding Specificity: AA 1-30

Purpose: CrkRS Antibody / CDK12 / Cyclin-dependent kinase 12

Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for this CrkRS antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the CrkRS antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CrkRS antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CDK12

Target: CDK12 (CRKRS) (Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS))

Alternative Name: CrkRS

Background: CrkRS, also known as Cdc2-related kinase, arginine/serine-rich, CDK12 and Cyclin-dependent kinase 12, is a cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. It also regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability.

UniProt: Q9NYV4