TYMS antibody (AA 1-313)

Catalog No. ABIN7869182

This Rabbit Polyclonal antibody specifically detects TYMS in WB, IF, ELISA and IHC (p). It exhibits reactivity toward Human, Rat and Monkey.

Quick Overview for TYMS antibody (AA 1-313) (ABIN7869182)

Target: TYMS (Thymidylate Synthetase (TYMS))

Reactivity: Human, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYMS antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TYMS Antibody

Binding Specificity: AA 1-313

Purpose: TYMS Antibody / Thymidylate Synthase

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids M1-V313) was used as the immunogen for the TYMS antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TYMS antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TYMS antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TYMS

Target: TYMS (Thymidylate Synthetase (TYMS))

Alternative Name: TYMS

Background: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy.

UniProt: P04818

Pathways: Mitotic G1-G1/S Phases