MAP3K2 antibody (AA 1-364)

Catalog No. ABIN7869256

The Rabbit Polyclonal anti-MAP3K2 antibody (ABIN7869256) specifically detects MAP3K2 in WB, ELISA and IF. The antibody is reactive with Human and Rat samples.

Quick Overview for MAP3K2 antibody (AA 1-364) (ABIN7869256)

Target: MAP3K2 (Mitogen-Activated Protein Kinase Kinase Kinase 2 (MAP3K2))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAP3K2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-MAP3K2 Antibody

Binding Specificity: AA 1-364

Purpose: MEKK2 Antibody

Purification: Affinity purified

Immunogen: A human recombinant partial protein (amino acids M1-Q364) was used as the immunogen for the MEKK2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MEKK2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MEKK2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MAP3K2

Target: MAP3K2 (Mitogen-Activated Protein Kinase Kinase Kinase 2 (MAP3K2))

Alternative Name: MEKK2

Background: MAP3K2, mitogen-activated protein kinase kinase kinase 2, also known as MEKK2, belongs to the mitogen-activated protein kinase (MAPK) kinase kinase gene family, which is involved in regulating multiple MAPK signaling pathways. Endogenous MAP3K2 localized mainly to the cytosol of unstimulated HeLa cells and rat fibroblasts. The MAP3K2 gene is mapped to chromosome 2 by the International Radiation Hybrid Mapping Consortium. MAP3K2 is a major upstream activator of the JNK, MAPK cascade. MAP3K2 was identifies as 1 of 6 kinases that regulate different steps of the caveolar cycle. Silencing of MAP3K2 strongly reduced kiss-and-run dynamics, leading to an accumulation of caveolar structures at the cell surface without affecting caveolae coat assembly or clustering.

UniProt: Q9Y2U5

Pathways: MAPK Signaling