PAX6 antibody (AA 1-401)

Catalog No. ABIN7869319

The Rabbit Polyclonal anti-PAX6 antibody (ABIN7869319) specifically detects PAX6 in WB and IF. The antibody is reactive with Zebrafish (Danio rerio) samples.

Quick Overview for PAX6 antibody (AA 1-401) (ABIN7869319)

Target: PAX6 (Paired Box 6 (PAX6))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAX6 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-PAX6 Antibody

Binding Specificity: AA 1-401

Purpose: Zebrafish Pax6 Antibody / Pax6a / Pax6b

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Pax6 recombinant protein (amino acids M1-M401) was used as the immunogen for the Zebrafish Pax6 antibody. This antibody will detect isoforms a & b.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Pax6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Pax6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PAX6

Target: PAX6 (Paired Box 6 (PAX6))

Alternative Name: Pax6

Background: Paired box protein 6 (Pax6) is a highly conserved transcription factor that plays a central role in the development of the eye, central nervous system, and pancreas. In zebrafish (Danio rerio), Pax6 is encoded by two paralogous genes, pax6a and pax6b, both of which are essential for ocular morphogenesis, neurogenesis, and endocrine cell differentiation.

During embryogenesis, zebrafish Pax6 is expressed in the forebrain, optic vesicles, retina, and spinal cord, where it regulates the expression of genes critical for cell fate determination and tissue patterning. Pax6 is a key regulator of eye field specification and is required for the proper formation of structures such as the lens, retina, and optic tectum. In addition, it contributes to pancreatic islet cell development, particularly in the differentiation of insulin-producing Beta-cells.

Given its evolutionary conservation and well-characterized functions, zebrafish Pax6 is widely used as a model for studying ocular development, neural differentiation, congenital eye disorders (e.g., aniridia), and transcriptional control of organogenesis.

UniProt: P26630

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis