MAZ antibody (AA 1-430)

Catalog No. ABIN7869353

This Rabbit Polyclonal antibody specifically detects MAZ in WB, ELISA, IF, ICC and FACS. It exhibits reactivity toward Human.

Quick Overview for MAZ antibody (AA 1-430) (ABIN7869353)

Target: MAZ (MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) (MAZ))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAZ antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Product Details anti-MAZ Antibody

Binding Specificity: AA 1-430

Purpose: MAZ Antibody / Myc associated zinc finger protein

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human MAZ recombinant protein (Position: M1-E430) was used as the immunogen for the MAZ antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MAZ antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MAZ antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MAZ

Target: MAZ (MYC-Associated Zinc Finger Protein (Purine-Binding Transcription Factor) (MAZ))

Alternative Name: MAZ

Background: MAZ antibody detects Myc associated zinc finger protein, encoded by the MAZ gene. Myc associated zinc finger protein is a transcription factor that regulates gene expression through GC-rich DNA elements and is involved in cell growth, apoptosis, and oncogenesis. MAZ antibody provides researchers with a critical reagent for studying transcriptional regulation and cancer biology.

Myc associated zinc finger protein belongs to the Kruppel family of zinc finger proteins and contains six C2H2-type zinc fingers. Research using MAZ antibody has shown that it binds to GC-rich promoter elements and initiator regions, where it regulates transcription of a wide range of genes. These include c-Myc, VEGF, and insulin receptor genes, linking MAZ to proliferation, angiogenesis, and metabolism.

Studies with MAZ antibody have revealed that the protein has dual transcriptional roles, functioning as both an activator and repressor depending on context. It recruits transcriptional co-regulators and chromatin remodelers, fine-tuning expression of growth-related genes. This versatility makes MAZ a central node in transcriptional networks controlling development and disease.

Dysregulation of Myc associated zinc finger protein has been associated with cancer, cardiovascular disease, and neurodegeneration. Research using MAZ antibody has shown that overexpression promotes tumor growth and angiogenesis by upregulating VEGF and c-Myc. It has also been implicated in atherosclerosis, where it regulates vascular smooth muscle proliferation, and in neurodegenerative disorders, where altered transcription contributes to pathology.

MAZ antibody is commonly used in chromatin immunoprecipitation, western blotting, and immunohistochemistry. Chromatin immunoprecipitation identifies promoter binding sites, western blotting quantifies expression in normal and cancer tissues, and immunohistochemistry demonstrates nuclear localization in proliferating cells. These applications make MAZ antibody valuable for transcriptional and oncogenesis research.

By supplying validated MAZ antibody reagents, NSJ Bioreagents supports studies into transcriptional control, oncogenesis, and vascular biology. Detection of Myc associated zinc finger protein provides researchers with insight into how zinc finger proteins regulate gene expression and disease.

UniProt: P56270

Pathways: Chromatin Binding