INSIG1 antibody (AA 1-87)

Catalog No. ABIN7869598

The Rabbit Polyclonal anti-INSIG1 antibody (ABIN7869598) specifically detects INSIG1 in WB, ELISA, IF, FACS and IHC (p). The antibody is reactive with Human samples.

Quick Overview for INSIG1 antibody (AA 1-87) (ABIN7869598)

Target: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INSIG1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-INSIG1 Antibody

Binding Specificity: AA 1-87

Purpose: Insulin-induced gene 1 Antibody / INSIG1

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (amino acids M1-R87) was used as the immunogen for the Insulin-induced gene 1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Insulin-induced gene 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Insulin-induced gene 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for INSIG1

Target: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Alternative Name: Insulin-induced gene 1

Background: Insulin induced gene 1, also known as INSIG1, is a protein which in humans is encoded by the INSIG1 gene. This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants.

UniProt: O15503

Pathways: ER-Nucleus Signaling