TIMM10 antibody (AA 1-90)

Catalog No. ABIN7869608

This Rabbit Polyclonal antibody specifically detects TIMM10 in ELISA, WB, IHC, IF, FACS and ICC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TIMM10 antibody (AA 1-90) (ABIN7869608)

Target: TIMM10 (Translocase of Inner Mitochondrial Membrane 10 (TIMM10))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIMM10 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Product Details anti-TIMM10 Antibody

Binding Specificity: AA 1-90

Purpose: TIMM10 Antibody / TIM10 / Mitochondrial import inner membrane translocase subunit Tim10

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human TIM10/TIMM10 recombinant protein (Position: M1-A90) was used as the immunogen for the TIMM10 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TIMM10 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TIMM10 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TIMM10

Target: TIMM10 (Translocase of Inner Mitochondrial Membrane 10 (TIMM10))

Alternative Name: TIMM10

Background: TIMM10 antibody detects Mitochondrial import inner membrane translocase subunit Tim10, a small chaperone protein essential for protein transport across the mitochondrial inner membrane. The UniProt recommended name is Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10). Also known as Tim10, this protein is a central component of the TIM22 complex, which imports and assembles metabolite carrier proteins into the inner membrane.

Functionally, TIMM10 antibody identifies a 103-amino-acid protein residing in the mitochondrial intermembrane space. TIMM10 forms a hexameric complex with TIMM9 to guide hydrophobic precursor proteins through the aqueous intermembrane environment to the TIM22 translocase. This chaperone-mediated import system maintains mitochondrial protein homeostasis and bioenergetic function.

The TIMM10 gene is located on chromosome 11q13.1 and is expressed in energy-demanding tissues such as heart, brain, and skeletal muscle. TIMM10 ensures proper import of metabolite carriers, including the ADP/ATP translocase and phosphate carrier, which are critical for mitochondrial metabolism.

Pathologically, defects in TIMM10 or its partner subunits lead to mitochondrial protein import deficiencies and oxidative phosphorylation defects. Impaired TIMM10 function can contribute to neurodegenerative and metabolic diseases. Research using TIMM10 antibody supports studies in mitochondrial biology, protein import, and bioenergetics.

TIMM10 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect mitochondrial translocase components. NSJ Bioreagents provides TIMM10 antibody reagents optimized for mitochondrial function, energy metabolism, and protein transport research.

Structurally, Mitochondrial import inner membrane translocase subunit Tim10 adopts a twin CX3C motif stabilized by disulfide bonds, forming a compact structure for substrate chaperoning. This antibody enables investigation of TIMM10's role in mitochondrial protein import and inner membrane assembly.

UniProt: P62072

Pathways: Sensory Perception of Sound, SARS-CoV-2 Protein Interactome