Cyclin E1 antibody (AA 10-176)

Catalog No. ABIN7869690

The Mouse Monoclonal anti-Cyclin E1 antibody is suitable to detect Cyclin E1 in samples from Human. It has been validated for ELISA.

Quick Overview for Cyclin E1 antibody (AA 10-176) (ABIN7869690)

Target: Cyclin E1 (CCNE1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cyclin E1 antibody is un-conjugated

Application: ELISA

Clone: CCNE1-2587

Product Details anti-Cyclin E1 Antibody

Binding Specificity: AA 10-176

Purpose: Cyclin E1 Antibody / CCNE1

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 10-176) was used as the immunogen for this Cyclin E1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Cyclin E1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Cyclin E1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Cyclin E1

Target: Cyclin E1 (CCNE1)

Alternative Name: Cyclin E1

Background: Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.

UniProt: P24864

Pathways: Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Mitotic G1-G1/S Phases