Cathepsin D antibody (AA 104-250)

Catalog No. ABIN7869961

The Mouse Monoclonal anti-Cathepsin D antibody (Clone CTSD-3082) (ABIN7869961) specifically detects Cathepsin D in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Cathepsin D antibody (AA 104-250) (ABIN7869961)

Target: Cathepsin D (CTSD)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cathepsin D antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CTSD-3082

Product Details anti-Cathepsin D Antibody

Binding Specificity: AA 104-250

Purpose: Cathepsin D Antibody

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 104-250) was used as the immunogen of the Cathepsin D antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Cathepsin D antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Cathepsin D antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Cathepsin D

Target: Cathepsin D (CTSD)

Alternative Name: Cathepsin D

Background: Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 52 kDa preprocathepsin D that is cleaved and glycosylated to form a 48 kDa procathepsin D and then further cleaved to produce 34 kDa and 14 kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

UniProt: P07339

Pathways: Peptide Hormone Metabolism