Mannose Receptor antibody (AA 1100-1400)

Catalog No. ABIN7870106

This Mouse Monoclonal antibody specifically detects Mannose Receptor in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Mannose Receptor antibody (AA 1100-1400) (ABIN7870106)

Target: Mannose Receptor (MR)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Mannose Receptor antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MRC1-9457

Product Details anti-Mannose Receptor Antibody

Binding Specificity: AA 1100-1400

Purpose: Mannose Receptor Antibody / MRC1 / CD206

Purification: Protein G affinity

Immunogen: A portion of amino acids 1100-1400 from human Macrophage mannose receptor 1 protein was used as the immunogen for the Mannose Receptor antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Mannose Receptor antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Mannose Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Mannose Receptor

Target: Mannose Receptor (MR)

Alternative Name: Mannose Receptor

Background: CD206, also known as macrophage mannose receptor type C (MMR, MRC1L1 and MRC1), is a type I membrane receptor protein. It is an phagocytic and endocytic receptor that can recognize carbohydrate ligands in target molecules. The extracellular portion of the protein includes eight C-type carbohydrate recognition domains (CRD) which are clustered together to achieve higher affinity binding to saccharides. CD206 is found on macrophages and on endothelial cells of the liver and is the only known example of a C-type lectin that contains multiple C-type CRDs. CD206 mediates the endocytosis of glycoproteins by macrophages and binds high-mannose structures on the surface of potentially pathogenic viruses, fungi and bacteria enabling them to be neutralized by phagocytic engulfment. During inflammation, CD206 is crucial for rapid clearance of several mannose-bearing serum glycoproteins but does not regulate the initiation of inflammation. CD206 is primarily expressed in mature tissue macrophages and immature dendritic cells, as well as hepatic and lymphatic endothelial cells, retinal pigmental epithelium (RPE) and mesangial cells.

UniProt: P22897