NCOR2 antibody (AA 1162-1362)

Catalog No. ABIN7870243

The Rabbit Polyclonal anti-NCOR2 antibody (ABIN7870243) specifically detects NCOR2 in WB, ELISA, IHC, IF, ICC and FACS. The antibody is reactive with Human samples.

Quick Overview for NCOR2 antibody (AA 1162-1362) (ABIN7870243)

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOR2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Product Details anti-NCOR2 Antibody

Binding Specificity: AA 1162-1362

Purpose: NCOR2 Antibody / Nuclear receptor corepressor 2

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human NCOR2 recombinant protein (Position: A1162-S1362) was used as the immunogen for the NCOR2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the NCOR2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the NCOR2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for NCOR2

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Alternative Name: NCOR2

Background: The NCOR2 antibody targets Nuclear receptor corepressor 2, a transcriptional regulator encoded by the NCOR2 gene. Also known as silencing mediator for retinoid and thyroid hormone receptors (SMRT), this large nuclear protein functions as a scaffold that recruits histone deacetylases (HDACs) and other chromatin-modifying enzymes to suppress gene transcription. Nuclear receptor corepressor 2 interacts with unliganded nuclear hormone receptors, transcription factors, and coregulator complexes to fine-tune gene expression across diverse physiological systems. The NCOR2 antibody allows researchers to explore this protein's roles in transcriptional repression, cell differentiation, and metabolic control.

Nuclear receptor corepressor 2 contains multiple repression domains, nuclear receptori 1/2interaction motifs, and regions that bind HDAC3. By forming multiprotein complexes, NCOR2 promotes chromatin condensation and transcriptional silencing through histone deacetylation. The NCOR2 antibody enables visualization of this protein in nuclear extracts and tissue samples, supporting studies that examine gene regulation by thyroid hormone, retinoic acid, glucocorticoid, and estrogen receptors. Through these interactions, NCOR2 modulates key pathways governing metabolism, development, and circadian rhythm.

Mutations or altered expression of NCOR2 disrupt hormonal and metabolic balance, contributing to endocrine and developmental disorders. In addition, aberrant nuclear receptor corepressor 2 function has been linked to oncogenesis, particularly in breast and prostate cancers, where loss of repression leads to hormone-independent growth. The NCOR2 antibody is used to assess expression levels and nuclear localization patterns, helping identify correlations between corepressor dysfunction and tumor progression. By supporting detection of NCOR2 in cancer tissues, this antibody aids in understanding transcriptional misregulation associated with tumorigenesis.

Beyond hormone receptor signaling, NCOR2 coordinates repression of inflammatory and immune genes by interacting with transcription factors such as NF-?B and STATs. It participates in maintaining immune tolerance and suppressing chronic inflammation. The NCOR2 antibody enables functional studies into these processes, revealing how corepressor complexes shape immune gene expression. In the central nervous system, NCOR2 also influences neuronal differentiation and synaptic plasticity, underscoring its role as a global regulator of chromatin dynamics.

The NCOR2 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry, exhibiting strong nuclear staining consistent with its role as a transcriptional corepressor. NSJ Bioreagents provides this antibody with high specificity and reproducibility for studies of epigenetic control and receptor signaling. By enabling accurate detection of Nuclear receptor corepressor 2, the NCOR2 antibody supports ongoing research into chromatin remodeling, transcriptional regulation, and disease mechanisms tied to epigenetic imbalance.

UniProt: Q9Y618

Pathways: Notch Signaling, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha