E2F5 antibody (AA 121-346)

Catalog No. ABIN7870319

This Rabbit Polyclonal antibody specifically detects E2F5 in WB, ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for E2F5 antibody (AA 121-346) (ABIN7870319)

Target: E2F5

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This E2F5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-E2F5 Antibody

Binding Specificity: AA 121-346

Purpose: E2F5 Antibody

Purification: Antigen affinity purified

Immunogen: Recombinant human E2F5 protein (amino acids C121-Y346) was used as the immunogen for the E2F5 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the E2F5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the E2F5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for E2F5

Target: E2F5

Alternative Name: E2F5

Background: Transcription factor E2F5 is a protein that in humans is encoded by the E2F5 gene. The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms.

UniProt: Q15329