TXNIP antibody (AA 122-152)

Catalog No. ABIN7870330

The Rabbit Polyclonal anti-TXNIP antibody (ABIN7870330) specifically detects TXNIP in WB, ELISA and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for TXNIP antibody (AA 122-152) (ABIN7870330)

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXNIP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-TXNIP Antibody

Binding Specificity: AA 122-152

Purpose: Thioredoxin-interacting protein Antibody / TXNIP

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (amino acids D122-N152) was used as the immunogen for the Thioredoxin-interacting protein antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Thioredoxin-interacting protein antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Thioredoxin-interacting protein antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TXNIP

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Alternative Name: Thioredoxin-interacting protein

Background: Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene. This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants.

UniProt: Q9H3M7

Pathways: Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome