TP53BP1 antibody (AA 1239-1972)

Catalog No. ABIN7870362

The Rabbit Polyclonal anti-TP53BP1 antibody is suitable to detect TP53BP1 in samples from Human. It has been validated for WB, ELISA, IF, FACS and IHC (p).

Quick Overview for TP53BP1 antibody (AA 1239-1972) (ABIN7870362)

Target: TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TP53BP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TP53BP1 Antibody

Binding Specificity: AA 1239-1972

Purpose: P53 binding protein 1 Antibody / 53BP1

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids H1239-H1972) was used as the immunogen for the p53 binding protein 1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the p53 binding protein 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the p53 binding protein 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TP53BP1

Target: TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))

Alternative Name: P53 binding protein 1

Background: TP53BP1 (Tumor Protein p53-Binding Protein 1), also called 53BP1, is a protein that in humans is encoded by the TP53BP1 gene. Iwabuchi et al.(1998) mapped the TP53BP1 gene to 15q15-q21 by FISH. Iwabuchi et al.(1994) showed that TP53BP1 binds to the conformationally sensitive central domain of wildtype p53 but not to mutant p53 in vitro. Immunoblot analysis by Iwabuchi et al.(1998) showed that expression of TP53BP1 or TP53BP2 enhances the transactivation function of p53 and induces the expression of p21(CDKN1A). Wang et al.(2002) used small interfering RNA directed against TP53BP1 in mammalian cells to demonstrate that TP53BP1 is a key transducer of the DNA damage checkpoint signal. TP53BP1 was required for p53 accumulation, G2/M checkpoint arrest, and the intra-S-phase checkpoint in response to ionizing radiation.

UniProt: Q12888

Pathways: DNA Damage Repair