LEF1 antibody (AA 14-274)

Catalog No. ABIN7870624

The Rabbit Polyclonal anti-LEF1 antibody (ABIN7870624) specifically detects LEF1 in WB, ELISA, IF and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for LEF1 antibody (AA 14-274) (ABIN7870624)

Target: LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LEF1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-LEF1 Antibody

Binding Specificity: AA 14-274

Purpose: TCF1 alpha Antibody / LEF1 / Lymphoid enhancer-binding factor 1

Purification: Affinity purified

Immunogen: An E. coli-derived human protein (amino acids D14-H274) was used as the immunogen for the TCF1 alpha antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TCF1 alpha antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TCF1 alpha antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for LEF1

Target: LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

Alternative Name: TCF1 alpha

Background: Lymphoid enhancer-binding factor 1 (LEF1), also called T cell-specific transcription factor 1-alpha (TCF1 alpha) is a protein that in humans is encoded by the LEF1 gene. This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.

UniProt: Q9UJU2

Pathways: WNT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Hormone Metabolic Process, Nuclear Hormone Receptor Binding, Chromatin Binding