LCK antibody (pTyr505) (Biotin)

Catalog No. ABIN743590

This Rabbit Polyclonal antibody specifically detects LCK in ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for LCK antibody (pTyr505) (Biotin) (ABIN743590)

Target: LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LCK antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-LCK Antibody (Biotin)

Binding Specificity: pTyr505

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Lck around the phosphorylation site of Tyr505

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for LCK

Target: LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))

Alternative Name: LCK

Background:

Synonyms: LCK phospho Y505, LCK phospho Tyr505, p-LCK Tyr505, p56-LCK, Lymphocyte cell-specic protein-tyrosine kinase, LSK, T cell-specic protein-tyrosine kinase, Lck p56, LSK, Lymphocyte Specic Protein Tyrosine Kinase, Membrane associated protein tyrosine kinase, Oncogene lck, P56 LCK, p56LSTRA protein tyrosine kinase, p56lck, pp58 lck, pp58lck, Proto oncogene tyrosine protein kinase LCK, Protooncogene tyrosine protein kinase LCK, T cell specic protein tyrosine kinase, T lymphocyte specic protein tyrosine kinase p56lck, YT 16, YT16, LCK_HUMAN.

Background: This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008].

Gene ID: 3932

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling