XPC antibody (AA 146-838)

Catalog No. ABIN7870736

This Rabbit Polyclonal antibody specifically detects XPC in WB, ELISA, FACS and IF. It exhibits reactivity toward Human, Rat, Mouse and Monkey.

Quick Overview for XPC antibody (AA 146-838) (ABIN7870736)

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Reactivity: Human, Rat, Mouse, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XPC antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-XPC Antibody

Binding Specificity: AA 146-838

Purpose: XPC Antibody

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids D146-E838) was used as the immunogen for the XPC antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the XPC antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the XPC antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for XPC

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Alternative Name: XPC

Background: Xeroderma pigmentosum, complementation group C, also known as XPC, is a protein which in humans is encoded by the XPC gene. The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

UniProt: Q01831

Pathways: p53 Signaling, DNA Damage Repair