Paired Box 3 antibody (AA 150-350)

Catalog No. ABIN7870939

The Mouse Monoclonal anti-Paired Box 3 antibody (Clone PAX3-8424) (ABIN7870939) specifically detects Paired Box 3 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Paired Box 3 antibody (AA 150-350) (ABIN7870939)

Target: Paired Box 3 (PAX3)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Paired Box 3 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PAX3-8424

Product Details anti-Paired Box 3 Antibody

Binding Specificity: AA 150-350

Purpose: Paired box 3 Antibody / PAX3

Purification: Protein G affinity

Immunogen: A portion of amino acids 150-350 from human PAX3 protein was used as the immunogen for the Paired box 3 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Paired box 3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Paired box 3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Paired Box 3

Target: Paired Box 3 (PAX3)

Alternative Name: Paired box 3

Background: Pax genes contain paired domains that share strong homology to genes in Drosophila which are involved in programming early development. The product of the PAX3 gene is a DNA-binding protein expressed during early neurogenesis. Pax-3 is a protein containing both a paired domain and a paired-type homeodomain. During early neurogenesis, Pax-3 expression is limited to mitotic cells in the ventricular zone of the developing spinal cord and to distinct regions in the hindbrain, midbrain and diencephalon. In 10-12 day embryos, expression of Pax-3 is also seen in neural crest cells of the developing spinal ganglia, the craniofacial mesectoderm and in limb mesenchyme. Mutations in the MITF and Pax-3 genes, encoding transcription factors, are responsible for Waardenburg syndrome II (WSII) and WSI/WSIII, respectively.

UniProt: P23760

Pathways: Sensory Perception of Sound, Tube Formation