PAWR antibody (AA 160-255)

Catalog No. ABIN7871097

The Rabbit Polyclonal anti-PAWR antibody is suitable to detect PAWR in samples from Human. It has been validated for WB, ELISA, IF and FACS.

Quick Overview for PAWR antibody (AA 160-255) (ABIN7871097)

Target: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAWR antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-PAWR Antibody

Binding Specificity: AA 160-255

Purpose: PAWR Antibody / PRKC apoptosis WT1 regulator protein / Par4

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (amino acids R160-D255) was used as the immunogen for the PAWR antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PAWR antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PAWR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PAWR

Target: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Alternative Name: PAWR

Background: PRKC apoptosis WT1 regulator protein, or Prostate apoptosis response-4, is a tumor-suppressor protein coded for in the human by the PAWR gene, that induces apoptosis in cancer cells, but not in normal cells. This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.

UniProt: Q96IZ0