TAB2 antibody (AA 169-522)

Catalog No. ABIN7871204

This Rabbit Polyclonal antibody specifically detects TAB2 in WB, ELISA, FACS and IHC (p). It exhibits reactivity toward Human.

Quick Overview for TAB2 antibody (AA 169-522) (ABIN7871204)

Target: TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TAB2 Antibody

Binding Specificity: AA 169-522

Purpose: TAB2 Antibody

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids Q169-K522) was used as the immunogen for the TAB2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TAB2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TAB2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TAB2

Target: TAB2 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2))

Alternative Name: TAB2

Background: Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, also known as TAB2, is an enzyme that in humans is encoded by the MAP3K7IP2 gene. The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. TAB2 functionally links TAK1 to TRAF6. What's more, TAB2 can act as a sensor for inflammatory signals by serving as a molecular beacon for recruitment of MEKK1(MAP3K1), which in turn mediated dismissal of the NCOR/HDAC complex and permitted derepression of AR and estrogen receptor target genes.

UniProt: Q9NYJ8

Pathways: TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway