ITCH antibody (AA 17-358)

Catalog No. ABIN7871227

The Rabbit Polyclonal anti-ITCH antibody (ABIN7871227) specifically detects ITCH in WB, ELISA, FACS, IF and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for ITCH antibody (AA 17-358) (ABIN7871227)

Target: ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITCH antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ITCH Antibody

Binding Specificity: AA 17-358

Purpose: AIP4 Antibody / ITCH

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids K17-E358) was used as the immunogen for the AIP4 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the AIP4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the AIP4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ITCH

Target: ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))

Alternative Name: AIP4

Background: ITCH is an ubiquitin-conjugating enzyme. This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

UniProt: Q96J02

Pathways: Activation of Innate immune Response, CXCR4-mediated Signaling Events