SELPLG antibody (AA 18-420)

Catalog No. ABIN7871418

The Rabbit Polyclonal anti-SELPLG antibody is suitable to detect SELPLG in samples from Mouse and Rat. It has been validated for FACS, WB, ELISA and IHC (p).

Quick Overview for SELPLG antibody (AA 18-420) (ABIN7871418)

Target: SELPLG (Selectin P Ligand (SELPLG))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SELPLG antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SELPLG Antibody

Binding Specificity: AA 18-420

Purpose: Psgl-1 Antibody / Selplg

Purification: Affinity purified

Immunogen: Recombinant rat protein (amino acids L18-P420) was used as the immunogen for the Psgl-1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Psgl-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Psgl-1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SELPLG

Target: SELPLG (Selectin P Ligand (SELPLG))

Alternative Name: Psgl-1

Background: Selectin P ligand, also known as SELPLG or CD162 (cluster of differentiation 162), is a human gene. It is mapped to 12q16. This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.

UniProt: Q8K5B0