IFI16 antibody (AA 183-743)

Catalog No. ABIN7871472

The Mouse Monoclonal anti-IFI16 antibody is suitable to detect IFI16 in samples from Human. It has been validated for WB, IF and FACS.

Quick Overview for IFI16 antibody (AA 183-743) (ABIN7871472)

Target: IFI16 (Interferon, gamma-Inducible Protein 16 (IFI16))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IFI16 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: 2I3D7

Product Details anti-IFI16 Antibody

Binding Specificity: AA 183-743

Purpose: IFI16 Antibody / Gamma-interferon-inducible protein 16

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids E183-K743) was used as the immunogen for the IFI16 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the IFI16 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the IFI16 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for IFI16

Target: IFI16 (Interferon, gamma-Inducible Protein 16 (IFI16))

Alternative Name: IFI16

Background: Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene. This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniProt: Q16666

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Autophagy, Inflammasome