CD226 antibody (AA 19-254)

Catalog No. ABIN7871578

The Rabbit Polyclonal anti-CD226 antibody (ABIN7871578) specifically detects CD226 in WB, FACS and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for CD226 antibody (AA 19-254) (ABIN7871578)

Target: CD226

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD226 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA

Product Details anti-CD226 Antibody

Binding Specificity: AA 19-254

Purpose: DNAM-1 Antibody / CD226

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids E19-A254) was used as the immunogen for the DNAM-1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the DNAM-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the DNAM-1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CD226

Target: CD226

Alternative Name: DNAM-1

Background: DNAM 1, also known as CD226, is a receptor expressed by peripheral blood T lymphocytes that is involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T lymphocytes. DNAM 1 is broadly expressed on T cells, NK cells, platelets, monocytes and a subset of B cells. DNAM-1 is also expressed by a subset of CD3 positive thymocytes. This antibody is reported to inhibit T- and NK cell mediated cytotoxicity against tumour cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells.

UniProt: Q15762

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints