ERCC1 antibody (AA 191-281)

Catalog No. ABIN7871657

This Mouse Monoclonal antibody specifically detects ERCC1 in ELISA. It exhibits reactivity toward Human.

Quick Overview for ERCC1 antibody (AA 191-281) (ABIN7871657)

Target: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ERCC1 antibody is un-conjugated

Application: ELISA

Clone: ERCC1-2683

Product Details anti-ERCC1 Antibody

Binding Specificity: AA 191-281

Purpose: ERCC1 Antibody

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 191-281 was used as the immunogen for the ERCC1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the ERCC1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the ERCC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for ERCC1

Target: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Alternative Name: ERCC1

Background: Excision Repair Cross Complementing 1 (ERCC1) is a mammalian nucleotide excision repair (NER) enzyme involved in repair of damaged DNA. ERCC1 is a homologous to RAD10 in Saccharomyces cerevisiae, which is required in mitotic intrachromosomal recombination and repair. ERCC1 is required in repair of cisplatin-induced DNA adducts and ultraviolet (UV)-induced DNA damage. High expression of ERCC1 has been linked to tumor progression in a variety of cancers including non-small cell lung cancer (NSCLC), squamous cell carcinoma of the head, ovarian cancer and esophageal cancer.

UniProt: P07992

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response