DBH antibody (AA 200-400)

Catalog No. ABIN7872013

The Mouse Monoclonal anti-DBH antibody (Clone DBH-7222) (ABIN7872013) specifically detects DBH in IHC (p). The antibody is reactive with Human samples.

Quick Overview for DBH antibody (AA 200-400) (ABIN7872013)

Target: DBH (Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DBH antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: DBH-7222

Product Details anti-DBH Antibody

Binding Specificity: AA 200-400

Purpose: Dopamine Beta-Hydroxylase Antibody / DBH

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 200-400) from the human protein was used as the immunogen for the Dopamine Beta-Hydroxylase antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the Dopamine Beta-Hydroxylase antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Dopamine Beta-Hydroxylase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for DBH

Target: DBH (Dopamine beta-Hydroxylase (Dopamine beta-Monooxygenase) (DBH))

Alternative Name: Dopamine Beta-Hydroxylase

Background: Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to noradrenaline in the biosynthesis of catecholamines. DBH is selectively expressed in noradrenergic and adrenergic neurons, as well as in neuroendocrine cells, and it serves as a specific protein marker for noradrenergic processes. The active form of DBH is a homotetramer, which is found in the lumen of synaptic vesicles of corresponding nerve cells, where it localizes to both the membrane and cytosol. DBH is induced by nerve growth factor and Insulin growth factor-1 and is regulated by intracellular second messengers protein kinase A, cyclic AMP, diacyl glycerol and Ca2+. Expression of DBH is transcriptionally mediated by Sp1, CREB and AP-1 proteins including c-Fos, c-Jun and JunD.

UniProt: P09172

Pathways: Carbohydrate Homeostasis