LAMP1 antibody (AA 200-400)

Catalog No. ABIN7872029

This Mouse Monoclonal antibody specifically detects LAMP1 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for LAMP1 antibody (AA 200-400) (ABIN7872029)

Target: LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LAMP1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: LAMP1-7456

Product Details anti-LAMP1 Antibody

Binding Specificity: AA 200-400

Purpose: CD107a Antibody / LAMP1

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 200-400) from the human protein was used as the immunogen for the CD107a antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the CD107a antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CD107a antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for LAMP1

Target: LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))

Alternative Name: CD107a

Background: Lysosome-associated membrane proteins (LAMP) are glycosylated type I membrane proteins that play a role in the biogenesis of the pigment melanin. LAMP-1 (also designated CD107a) and LAMP-2 (also designated CD107b) are involved in a variety of functions, including cellular adhesion, and are thought to participate in the process of tumor invasion and metastasis. Newly synthesized LAMP-1 and LAMP-2 proteins are sorted at the trans-Golgi network and are transported intracellularly via a pathway that is distinct from the Clathrincoated vesicles used for the mannose-6 phosphate receptor. LAMP-1 is expressed on the surface of Thrombin-activated but not resting platelets, and it is thought to be involved in the adhesive, prothrombic properties of these cells. Both LAMP-1 and LAMP-2 are involved in maintaining lysosome acidity and protecting the lysosomal membranes from autodigestion, and their expression is increased in patients with lysosomal storage disorders.

UniProt: P11279

Pathways: Autophagy