Recombinant Tyrosinase-Related Protein 1 antibody (AA 200-400)

Catalog No. ABIN7872064

The Rabbit Monoclonal anti-Tyrosinase-Related Protein 1 antibody (Clone TYRP1-8313R) (ABIN7872064) specifically detects Tyrosinase-Related Protein 1 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant Tyrosinase-Related Protein 1 antibody (AA 200-400) (ABIN7872064)

Target: Tyrosinase-Related Protein 1 (TYRP1)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Tyrosinase-Related Protein 1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: TYRP1-8313R

Product Details anti-Tyrosinase-Related Protein 1 Antibody

Binding Specificity: AA 200-400

Purpose: Tyrosinase-Related Protein-1 Antibody / TYRP1 (azide and preservative free)

Purification: Protein A affinity

Immunogen: A recombinant partial protein sequence (within amino acids 200-400) from the human protein was used as the immunogen for the Tyrosinase-Related Protein-1 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the Tyrosinase-Related Protein-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Tyrosinase-Related Protein-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Tyrosinase-Related Protein 1

Target: Tyrosinase-Related Protein 1 (TYRP1)

Alternative Name: Tyrosinase-Related Protein-1

Background: It reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

UniProt: P17643