Neuregulin 1 antibody (AA 21-242)

Catalog No. ABIN7872151

The Mouse Monoclonal anti-Neuregulin 1 antibody (Clone NRG1-2710) (ABIN7872151) specifically detects Neuregulin 1 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Neuregulin 1 antibody (AA 21-242) (ABIN7872151)

Target: Neuregulin 1 (NRG1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Neuregulin 1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: NRG1-2710

Product Details anti-Neuregulin 1 Antibody

Binding Specificity: AA 21-242

Purpose: Neuregulin-1 Antibody / NRG1

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 21-242) was used as the immunogen for the Neuregulin-1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Neuregulin-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Neuregulin-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Neuregulin 1

Target: Neuregulin 1 (NRG1)

Alternative Name: Neuregulin-1

Background: Neuregulin-1, also called Heregulin-1, is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

UniProt: Q02297

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation