Neuregulin 1 antibody (AA 21-242)

Catalog No. ABIN7872152

This Mouse Monoclonal antibody specifically detects Neuregulin 1 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Neuregulin 1 antibody (AA 21-242) (ABIN7872152)

Target: Neuregulin 1 (NRG1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Neuregulin 1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: HRGA1-1

Product Details anti-Neuregulin 1 Antibody

Binding Specificity: AA 21-242

Purpose: NRG1 Antibody / Neuregulin-1 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 21-242) was used as the immunogen for the NRG1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the NRG1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the NRG1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Neuregulin 1

Target: Neuregulin 1 (NRG1)

Alternative Name: NRG1

Background: Neuregulin-1, also called Heregulin-1, is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

UniProt: Q02297

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation