OAT antibody (AA 223-444)

Catalog No. ABIN7872379

The Rabbit Polyclonal anti-OAT antibody (ABIN7872379) specifically detects OAT in IHC (p). The antibody is reactive with Zebrafish (Danio rerio) samples.

Quick Overview for OAT antibody (AA 223-444) (ABIN7872379)

Target: OAT (Ornithine Aminotransferase (OAT))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OAT antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-OAT Antibody

Binding Specificity: AA 223-444

Purpose: Zebrafish Ornithine aminotransferase Antibody / Oat

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Ornithine aminotransferase recombinant protein (amino acids A223-F444) was used as the immunogen for the Zebrafish Ornithine aminotransferase antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Ornithine aminotransferase antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Ornithine aminotransferase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for OAT

Target: OAT (Ornithine Aminotransferase (OAT))

Alternative Name: Ornithine aminotransferase

Background: Ornithine aminotransferase, also known as OAT, is a mitochondrial enzyme that plays a key role in amino acid metabolism, particularly in the urea cycle and the synthesis of proline and glutamate. It catalyzes the reversible transamination of ornithine to glutamate semialdehyde, which is an important intermediate in nitrogen and energy metabolism.

In zebrafish, ornithine aminotransferase is expressed in multiple tissues including the liver, kidney, brain, and eye, reflecting its essential role in cellular homeostasis and metabolic balance. The zebrafish ornithine aminotransferase gene is an ortholog of the human OAT gene. Both proteins share high sequence similarity and conserved functional domains, supporting the use of zebrafish as a model for studying OAT related biology and disease.

Functionally, ornithine aminotransferase is critical for regulating the intracellular balance of ornithine and proline, which are important for collagen synthesis, antioxidant responses, and retinal function. In humans, mutations in the OAT gene are associated with a rare metabolic disorder known as gyrate atrophy of the choroid and retina, which leads to progressive vision loss. Zebrafish models have been used to study the developmental and physiological consequences of OAT deficiency, especially in ocular and hepatic systems.

Due to its evolutionary conservation and key metabolic functions, zebrafish ornithine aminotransferase is a valuable target in research areas including developmental biology, metabolism, neurobiology, and genetic disease modeling.

UniProt: F8W5L3