DERL1 antibody (AA 224-251)

Catalog No. ABIN7872381

The Rabbit Polyclonal anti-DERL1 antibody is suitable to detect DERL1 in samples from Human and Mouse. It has been validated for WB, IHC (p) and FACS.

Quick Overview for DERL1 antibody (AA 224-251) (ABIN7872381)

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DERL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-DERL1 Antibody

Binding Specificity: AA 224-251

Purpose: Derlin 1 Antibody / DERL1

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 224-251 from the human protein was used as the immunogen for the Derlin 1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Derlin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Derlin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for DERL1

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Alternative Name: Derlin 1

Background: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.

UniProt: Q9BUN8

Pathways: ER-Nucleus Signaling