GNS antibody (AA 224-341)

Catalog No. ABIN7872393

The Rabbit Polyclonal anti-GNS antibody is suitable to detect GNS in samples from Zebrafish (Danio rerio). It has been validated for WB and IHC (p).

Quick Overview for GNS antibody (AA 224-341) (ABIN7872393)

Target: GNS (Glucosamine (N-Acetyl)-6-Sulfatase (GNS))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GNS Antibody

Binding Specificity: AA 224-341

Purpose: Zebrafish Gnsa Antibody / N-acetylglucosamine-6-sulfatase

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived zebrafish Gnsa recombinant protein (amino acids W224-R341) was used as the immunogen for the Zebrafish Gnsa antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Gnsa antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Gnsa antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GNS

Target: GNS (Glucosamine (N-Acetyl)-6-Sulfatase (GNS))

Alternative Name: Gnsa

Background: N-acetylglucosamine-6-sulfatase, also known as glucosamine (N-acetyl)-6-sulfatase, is an enzyme that in humans is encoded by the GNS gene. The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome.

UniProt: Q4V902

Pathways: Glycosaminoglycan Metabolic Process