RAGE antibody (AA 24-320)

Catalog No. ABIN7872683

This Rabbit Polyclonal antibody specifically detects RAGE in WB and ELISA. It exhibits reactivity toward Mouse and Rat.

Quick Overview for RAGE antibody (AA 24-320) (ABIN7872683)

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAGE antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RAGE Antibody

Binding Specificity: AA 24-320

Purpose: Rage Antibody / Ager

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant mouse protein (amino acids Q24-E320) was used as the immunogen for the Rage antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Rage antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Rage antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for RAGE

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Alternative Name: Rage

Background: Enables S100 protein binding activity, advanced glycation end-product binding activity, and heparin binding activity. Involved in several processes, including cellular response to amyloid-beta, negative regulation of long-term synaptic potentiation, and positive regulation of cytokine production. Acts upstream of or within several processes, including induction of positive chemotaxis, negative regulation of advanced glycation end-product receptor activity, and positive regulation of macromolecule metabolic process. Located in extracellular space and plasma membrane. Is expressed in several structures, including alimentary system, brain, genitourinary system, hemolymphoid system gland, and lung. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple), cardiovascular system disease (multiple), cystic fibrosis, kidney failure (multiple), and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor).

UniProt: Q62151

Pathways: Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins