Metabotropic Glutamate Receptor 5 antibody (AA 24-560)

Catalog No. ABIN7872710

This Rabbit Polyclonal antibody specifically detects Metabotropic Glutamate Receptor 5 in WB, ELISA and FACS. It exhibits reactivity toward Rat, Human and Mouse.

Quick Overview for Metabotropic Glutamate Receptor 5 antibody (AA 24-560) (ABIN7872710)

Target: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Reactivity: Rat, Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Metabotropic Glutamate Receptor 5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-Metabotropic Glutamate Receptor 5 Antibody

Binding Specificity: AA 24-560

Purpose: GRM5 Antibody / Glutamate Metabotropic Receptor 5

Purification: Affinity purified

Immunogen: A human recombinant protein (amino acids E24-D560) was used as the immunogen for the GRM5 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GRM5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GRM5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Metabotropic Glutamate Receptor 5

Target: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Alternative Name: GRM5

Background: Metabotropic glutamate receptor 5 is a G protein-coupled receptor that in humans is encoded by the GRM5 gene. It is mapped to 11q14.2-q14.3. This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants.

UniProt: P41594

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity