Aquaporin 4 antibody (AA 247-323)

Catalog No. ABIN7872793

The Rabbit Polyclonal anti-Aquaporin 4 antibody (ABIN7872793) specifically detects Aquaporin 4 in WB, ELISA, FACS and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Aquaporin 4 antibody (AA 247-323) (ABIN7872793)

Target: Aquaporin 4 (AQP4)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aquaporin 4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Aquaporin 4 Antibody

Binding Specificity: AA 247-323

Purpose: Aquaporin 4 Antibody / AQP4

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids L247-V323) was used as the immunogen for the Aquaporin 4 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Aquaporin 4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Aquaporin 4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Aquaporin 4

Target: Aquaporin 4 (AQP4)

Alternative Name: Aquaporin 4

Background: Aquaporin 4 is found in the basolateral cell membrane of principal collecting duct cells and provides a pathway for water to exit these cells. The gene of AQP4 is mapped to 18q11.2-q12.1. Similar to other aquaporins, the AQP4 gene is composed of 4 exons encoding 127, 55, 27, and 92 amino acids separated by introns of 0.8, 0.3, and 5.2 kb. Unlike other aquaporins, an alternative coding initiation sequence (designated exon 0) was located 2.7 kb upstream of exon 1. When spliced together, M1 and the subsequent 10 amino acids are encoded by exon 0, the next 11 amino acids and M23 are encoded by exon 1. AQP4 is expressed in astrocytes and is upregulated by direct insult to the central nervous system. And AQP4 is the predominant water channel in the brain and has an important role in brain water homeostasis. It is abundant in mammalian brain and is concentrated in astrocytic foot processes at the blood-brain barrier.

UniProt: P55087

Pathways: Sensory Perception of Sound