Tyrosinase-Related Protein 1 antibody (AA 257-377)

Catalog No. ABIN7872962

This Mouse Monoclonal antibody specifically detects Tyrosinase-Related Protein 1 in ELISA and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Tyrosinase-Related Protein 1 antibody (AA 257-377) (ABIN7872962)

Target: Tyrosinase-Related Protein 1 (TYRP1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Tyrosinase-Related Protein 1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TYRP1-3280

Product Details anti-Tyrosinase-Related Protein 1 Antibody

Binding Specificity: AA 257-377

Purpose: Tyrosinase-Related Protein-1 Antibody / TRP1 / TYRP1

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 257-377) was used as the immunogen for this Tyrosinase-Related Protein-1 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Tyrosinase-Related Protein-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Tyrosinase-Related Protein-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Tyrosinase-Related Protein 1

Target: Tyrosinase-Related Protein 1 (TYRP1)

Alternative Name: Tyrosinase-Related Protein-1

Background: It reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

UniProt: P17643